InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gabarapl1

Summary

InnateDB Protein

IDBP-192066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabarapl1

Protein Name

gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1

Synonyms

3110025G09Rik; 9130422N19Rik; AI196471; Apg8l; Atg8l; GECI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032264

InnateDB Gene

IDBG-192064 (Gabarapl1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis and heart at high levels. {ECO:0000269PubMed:11414770}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0030659	cytoplasmic vesicle membrane
GO:0032590	dendrite membrane
GO:0032839	dendrite cytoplasm
GO:0044297	cell body