InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OLIG2

Summary

InnateDB Protein

IDBP-1921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OLIG2

Protein Name

oligodendrocyte lineage transcription factor 2

Synonyms

BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17;

Species

Homo sapiens

Ensembl Protein

ENSP00000331040

InnateDB Gene

IDBG-1917 (OLIG2)

Protein Structure

UniProt Annotation

Function

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Tissue Specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. {ECO:0000269PubMed:11498220, ECO:0000269PubMed:11526205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0021522	spinal cord motor neuron differentiation
GO:0021529	spinal cord oligodendrocyte cell differentiation
GO:0021530	spinal cord oligodendrocyte cell fate specification
GO:0021794	thalamus development
GO:0042552	myelination
GO:0045665	negative regulation of neuron differentiation
GO:0048663	neuron fate commitment
GO:0048709	oligodendrocyte differentiation
GO:0048714	positive regulation of oligodendrocyte differentiation