InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp30

Summary

InnateDB Protein

IDBP-192163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp30

Protein Name

ubiquitin specific peptidase 30

Synonyms

6330590F17Rik; AI851327; D5Ertd483e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031588

InnateDB Gene

IDBG-192161 (Usp30)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (By similarity). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. {ECO:0000250, ECO:0000269PubMed:24513856}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:24513856}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0008234	cysteine-type peptidase activity
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000422	mitochondrion degradation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination

Cellular Component

GO:0005575	cellular_component
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2140991

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UN04

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

100756

UniGene

RefSeq

NP_001028374

MGI ID

MGI Symbol

Usp30

OMIM

CCDS

CCDS19558

HPRD

IMGT

EMBL

AK078164 AK144578 AK162153 AK162269 BC038606

GenPept

AAH38606 BAC37154 BAE25944 BAE36756 BAE36827