Version 5.4
Homo sapiens Protein: SPESP1
Summary
InnateDB Protein IDBP-19218.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPESP1
Protein Name sperm equatorial segment protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312284
InnateDB Gene IDBG-547501 (SPESP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269PubMed:12773409}. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase).
Disease Associations
Tissue Specificity Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung. {ECO:0000269PubMed:12773409}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007340 acrosome reaction
GO:0007342 fusion of sperm to egg plasma membrane
Cellular Component
GO:0001669 acrosomal vesicle
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UW49
PhosphoSite PhosphoSite-Q6UW49
TrEMBL
UniProt Splice Variant
Entrez Gene 246777
UniGene
RefSeq NP_663633
HUGO HGNC:15570
OMIM 609399
CCDS CCDS10230
HPRD 15436
IMGT
EMBL AC087639 AF275321 AY358983 BC017998
GenPept AAH17998 AAM69364 AAQ89342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca