InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprs

Summary

InnateDB Protein

IDBP-192193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprs

Protein Name

protein tyrosine phosphatase, receptor type, S

Synonyms

AL022616; PTP; PTP-NU3; PTPNU-3; PTPsigma; Ptpt9; R-PTP-S; RPTPsigma;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084038

InnateDB Gene

IDBG-192187 (Ptprs)

Protein Structure

UniProt Annotation

Function

Interacts with LAR-interacting protein LIP.1. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum and cerebellum) and to a lesser extent in the heart and skeletal muscle. Also found in neuronal- derived cell lines. {ECO:0000269PubMed:7529177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0016311	dephosphorylation
GO:0021510	spinal cord development
GO:0021549	cerebellum development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0022038	corpus callosum development
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:97815

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108
PF07679

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt