InnateDB Protein
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IDBP-192323.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Clstn2
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Protein Name
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calsyntenin 2
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Synonyms
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2900042C18Rik; AI448973; Cs2; Cst-2; CSTN2; mKIAA4134;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000035027
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InnateDB Gene
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IDBG-192321 (Clstn2)
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Protein Structure
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Function |
May modulate calcium-mediated postsynaptic signals. {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269PubMed:12498782}. Golgi apparatus membrane {ECO:0000269PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.
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Disease Associations |
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Tissue Specificity |
Restricted to the brain. In the cerebral cortex, found in the somas and neuropil of all layers. Expressed at highest levels in neurons of cortical layers 5 and 6 and, at lower levels, in neurons of the upper layers. Highly expressed in Purkinje cells. Also found in a few scattered interneurons throughout the granule cell layer and occasionally in neurons in the molecular layer (at protein level). Present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern). {ECO:0000269PubMed:12498782}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929897
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InterPro |
IPR002126
Cadherin
IPR008985
Concanavalin A-like lectin/glucanases superfamily
IPR015919
Cadherin-like
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PFAM |
PF00028
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PRINTS |
PR00205
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PIRSF |
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SMART |
SM00112
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ER65
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PhosphoSite |
PhosphoSite-Q9ER65
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64085
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UniGene |
Mm.440903
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RefSeq |
NP_071714
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MGI ID |
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MGI Symbol |
Clstn2
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OMIM |
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CCDS |
CCDS40733
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HPRD |
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IMGT |
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EMBL |
AJ278069
AK048369
AK220500
BC063058
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GenPept |
AAH63058
BAC33313
BAD90297
CAC14887
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