InnateDB Protein
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IDBP-192383.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kctd11
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Protein Name
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potassium channel tetramerisation domain containing 11
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059107
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InnateDB Gene
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IDBG-192381 (Kctd11)
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Protein Structure
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Function |
Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. {ECO:0000269PubMed:12186855, ECO:0000269PubMed:16148242}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Weakly expressed in lung. In the cerebellum, higher expression in non proliferating external granule cells layer than in highly proliferating ones. {ECO:0000269PubMed:12186855, ECO:0000269PubMed:16148242}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2448712
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InterPro |
IPR003131
Potassium channel tetramerisation-type BTB domain
IPR011333
BTB/POZ fold
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PFAM |
PF02214
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K485
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
216858
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UniGene |
Mm.400739
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RefSeq |
NP_694783
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MGI ID |
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MGI Symbol |
Kctd11
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OMIM |
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CCDS |
CCDS24918
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HPRD |
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IMGT |
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EMBL |
AF465352
AK039558
AK161602
AK170258
BC052502
BC052734
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GenPept |
AAH52502
AAH52734
AAM95915
BAC30382
BAE36486
BAE41666
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