InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acap1

Summary

InnateDB Protein

IDBP-192392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acap1

Protein Name

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001631

InnateDB Gene

IDBG-192390 (Acap1)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity

Biological Process

GO:0007165	signal transduction
GO:0008150	biological_process
GO:0016042	lipid catabolic process
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005575	cellular_component
GO:0016020	membrane
GO:0055038	recycling endosome membrane

Protein Structure and Domains

PDB ID

MGI:2388270

InterPro

IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001164 Arf GTPase activating protein
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain

PFAM