Mus musculus Protein: Ube3b
Summary
InnateDB Protein IDBP-192466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube3b
Protein Name ubiquitin protein ligase E3B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000073652
InnateDB Gene IDBG-192464 (Ube3b)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed. High expression is observed in developing central nervous system. {ECO:0000269PubMed:12837265, ECO:0000269PubMed:23200864}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1891295
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000569 HECT
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00612
PF00632
PRINTS
PIRSF
SMART SM00015
SM00119
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ES34
PhosphoSite PhosphoSite-Q9ES34
TrEMBL Q8R0U4
UniProt Splice Variant
Entrez Gene 117146
UniGene Mm.28792
RefSeq NP_473434
MGI ID
MGI Symbol Ube3b
OMIM
CCDS CCDS19564
HPRD
IMGT
EMBL AF244362 BC023956 BC026415 BC034059 BC096743
GenPept AAG16783 AAH23956 AAH26415 AAH34059 AAH96743