Mus musculus Protein: Hcrtr1 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-192483.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Hcrtr1 | ||||||||
Protein Name | hypocretin (orexin) receptor 1 | ||||||||
Synonyms | |||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000030562 | ||||||||
InnateDB Gene | IDBG-192481 (Hcrtr1) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | Widely expressed. {ECO:0000269PubMed:15256537}. | ||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | MGI:2385650 | ||||||||
InterPro |
IPR000204
Orexin receptor family IPR000276 G protein-coupled receptor, rhodopsin-like IPR000611 Neuropeptide Y receptor family IPR004059 Orexin receptor 1 IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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PFAM |
PF00001
PF10320 |
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PRINTS |
PR01064
PR00237 PR01012 PR01521 |
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PIRSF | |||||||||
SMART | |||||||||
TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | P58307 | ||||||||
PhosphoSite | PhosphoSite-P58307 | ||||||||
TrEMBL | Q0VDP6 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 230777 | ||||||||
UniGene | Mm.246595 | ||||||||
RefSeq | NP_945197 | ||||||||
MGI ID | |||||||||
MGI Symbol | Hcrtr1 | ||||||||
OMIM | |||||||||
CCDS | CCDS18707 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AF394596 AK140137 AL606925 AY255599 AY336083 BC119582 BC119583 CU207372 CU210846 | ||||||||
GenPept | AAI19583 AAI19584 AAK71326 AAO85111 AAR01326 BAE24252 CAM45913 CAQ51584 CAQ51833 | ||||||||