InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Safb

Summary

InnateDB Protein

IDBP-192522.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Safb

Protein Name

scaffold attachment factor B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092849

InnateDB Gene

IDBG-192520 (Safb)

Protein Structure

UniProt Annotation

Function

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter. {ECO:0000269PubMed:19403048}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001047	core promoter binding
GO:0003676	nucleic acid binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0040007	growth
GO:0042445	hormone metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter