Version 5.4
Mus musculus Protein: Tmbim4
Summary
InnateDB Protein IDBP-192573.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmbim4
Protein Name transmembrane BAX inhibitor motif containing 4
Synonyms 0610007H07Rik; AU022431;
Species Mus musculus
Ensembl Protein ENSMUSP00000020446
InnateDB Gene IDBG-192571 (Tmbim4)
Protein Structure
UniProt Annotation
Function Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006915 apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0050848 regulation of calcium-mediated signaling
Cellular Component
GO:0000139 Golgi membrane
GO:0005795 Golgi stack
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915462
InterPro IPR006214 Bax inhibitor 1-related
PFAM PF01027
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DA39
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 68212
UniGene Mm.487755
RefSeq NP_080893
MGI ID
MGI Symbol Tmbim4
OMIM
CCDS CCDS24205
HPRD
IMGT
EMBL AK006207
GenPept BAB24458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca