InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alx4

Summary

InnateDB Protein

IDBP-192633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alx4

Protein Name

aristaless-like homeobox 4

Synonyms

lst;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047962

InnateDB Gene

IDBG-192631 (Alx4)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in skull and limb development.

Subcellular Localization

Nucleus.

Disease Associations

Note=Defects in Alx4 are the cause of Strong luxoid (lst) phenotype. At heterozygosity lst is characterized by preaxial abnormalities of the hindfeet and, very rarely, of the forefeet. Homozygotes show preaxial polydactyly of all four limbs, reductions and duplications of the radius, absence of the tibia, craniofacial defects, reduction of the pubis, and dorsal alopecia.

Tissue Specificity

Expressed in osteoblasts. Not expressed in brain, heart, intestine, kidney, liver, muscle, spleen and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0071837	HMG box domain binding

Biological Process

GO:0001942	hair follicle development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007517	muscle organ development
GO:0009791	post-embryonic development
GO:0009952	anterior/posterior pattern specification
GO:0035108	limb morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0042733	embryonic digit morphogenesis
GO:0042981	regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0048704	embryonic skeletal system morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0060021	palate development