InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mvk

Summary

InnateDB Protein

IDBP-192642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mvk

Protein Name

mevalonate kinase

Synonyms

2310010A05Rik; AI256848; AI414037; MK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036971

InnateDB Gene

IDBG-192640 (Mvk)

Protein Structure

UniProt Annotation

Function

May be a regulatory site in cholesterol biosynthetic pathway.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004496	mevalonate kinase activity
GO:0005524	ATP binding
GO:0042802	identical protein binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0016310	phosphorylation
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0050728	negative regulation of inflammatory response

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:107624

InterPro

IPR001174 Galactokinase/homoserine kinase
IPR006204 GHMP kinase N-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00288
PF08544

PRINTS

PR00960
PR00959

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R008