InnateDB Protein
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IDBP-192645.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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St3gal2
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Protein Name
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ST3 beta-galactoside alpha-2,3-sialyltransferase 2
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Synonyms
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AI429591; AW822065; Siat5; ST3GalII;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034197
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InnateDB Gene
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IDBG-192643 (St3gal2)
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Protein Structure
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Function |
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in brain and liver and to a lesser extent in heart and kidney. Scarcely detectable in lung, pancreas, spleen and submaxillary gland.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003836
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beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
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GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:99427
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR012163
Sialyltransferase
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF00777
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PRINTS |
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PIRSF |
PIRSF005557
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q11204
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q8BSA0
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UniProt Splice Variant |
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Entrez Gene |
20444
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UniGene |
Mm.413990
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RefSeq |
NP_033205
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MGI ID |
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MGI Symbol |
St3gal2
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OMIM |
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CCDS |
CCDS22667
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HPRD |
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IMGT |
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EMBL |
AK034863
AK053827
AK131653
AK134937
BC066064
CH466525
X76989
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GenPept |
AAH66064
BAC28859
BAC35543
BAE20742
BAE22346
CAA54294
EDL11478
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