InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ext2

Summary

InnateDB Protein

IDBP-192654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ext2

Protein Name

exostoses (multiple) 2

Synonyms

AI893565;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028623

InnateDB Gene

IDBG-192652 (Ext2)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.

Disease Associations

Tissue Specificity

Heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008375	acetylglucosaminyltransferase activity
GO:0015020	glucuronosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016758	transferase activity, transferring hexosyl groups
GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Biological Process

GO:0001503	ossification
GO:0001707	mesoderm formation
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006486	protein glycosylation
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0030154	cell differentiation
GO:0033692	cellular polysaccharide biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031227	intrinsic component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome