Mus musculus Protein: Wif1
Summary
InnateDB Protein IDBP-192733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wif1
Protein Name Wnt inhibitory factor 1
Synonyms AW107799; WIF-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000020439
InnateDB Gene IDBG-192731 (Wif1)
Protein Structure
UniProt Annotation
Function Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expression highest in heart and lung. Lower in brain and eye.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0045600 positive regulation of fat cell differentiation
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1344332
InterPro IPR000742 Epidermal growth factor-like domain
IPR003306 WIF domain
IPR013111 EGF-like domain, extracellular
IPR013309 Wnt inhibitory factor (WIF)-1
PFAM PF00008
PF02019
PF07974
PRINTS PR01901
PIRSF
SMART SM00181
SM00469
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUA1
PhosphoSite PhosphoSite-
TrEMBL Q3TYU1
UniProt Splice Variant
Entrez Gene 24117
UniGene Mm.402906
RefSeq NP_036045
MGI ID
MGI Symbol Wif1
OMIM
CCDS CCDS24209
HPRD
IMGT
EMBL AF122923 AK142443 AK158359 BC013268 CH466578
GenPept AAD25403 AAH13268 BAE25067 BAE34471 EDL24411