InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tchp

Summary

InnateDB Protein

IDBP-192772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tchp

Protein Name

trichoplein, keratin filament binding

Synonyms

A930031F18Rik; AV279199;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092009

InnateDB Gene

IDBG-192768 (Tchp)

Protein Structure

UniProt Annotation

Function

Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined, including brain, liver, small intestine, large intestine, lung and heart. Found concentrated in tubular structures within hepatocytes, and in the apical cortical region and desmosomes of the apical junctional domain in enterocytes of the small intestine. In the hair follicle, localized at the outer root sheath. Also expressed in blood vessels (at protein level). {ECO:0000269PubMed:15731013}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0030308	negative regulation of cell growth

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0045095	keratin filament
GO:0045179	apical cortex

Protein Structure and Domains

PDB ID

MGI:1925082

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TVW5

PhosphoSite

PhosphoSite-Q3TVW5

TrEMBL

UniProt Splice Variant

Entrez Gene

77832

UniGene

Mm.239698

RefSeq

NP_084268

MGI ID

MGI Symbol

Tchp

OMIM

CCDS

CCDS51624

HPRD

IMGT

EMBL

AK020912 AK083027 AK159947 BC043048 BC047930

GenPept

AAH43048 AAH47930 BAB32251 BAC38735 BAE35503