Version 5.4
Mus musculus Protein: Ranbp3
Summary
InnateDB Protein IDBP-192794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ranbp3
Protein Name RAN binding protein 3
Synonyms 2610024N24Rik; AA408221;
Species Mus musculus
Ensembl Protein ENSMUSP00000002445
InnateDB Gene IDBG-192792 (Ranbp3)
Protein Structure
UniProt Annotation
Function Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070412 R-SMAD binding
Biological Process
GO:0008150 biological_process
GO:0015031 protein transport
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1919060
InterPro IPR000156 Ran binding domain
PFAM PF00638
PRINTS
PIRSF
SMART SM00160
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CT10
PhosphoSite PhosphoSite-Q9CT10
TrEMBL
UniProt Splice Variant
Entrez Gene 71810
UniGene Mm.29608
RefSeq NP_082209
MGI ID
MGI Symbol Ranbp3
OMIM
CCDS CCDS28911
HPRD
IMGT
EMBL AK011541 AK133949 AK134696 AK155301 AK167731 BC145892 BC145894
GenPept AAI45893 AAI45895 BAB27684 BAE21946 BAE22245 BAE33176 BAE39772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca