Version 5.4
Mus musculus Protein: Esyt3
Summary
InnateDB Protein IDBP-192797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Esyt3
Protein Name extended synaptotagmin-like protein 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038757
InnateDB Gene IDBG-192795 (Esyt3)
Protein Structure
UniProt Annotation
Function Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0044232 organelle membrane contact site
Protein Structure and Domains
PDB ID MGI:1098699
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5DTI8
PhosphoSite PhosphoSite-Q5DTI8
TrEMBL
UniProt Splice Variant
Entrez Gene 272636
UniGene Mm.490440
RefSeq NP_808443
MGI ID
MGI Symbol Esyt3
OMIM
CCDS CCDS40739
HPRD
IMGT
EMBL AK086367 AK220532 BC118967
GenPept AAI18968 BAC39655 BAD90311

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca