InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aars

Summary

InnateDB Protein

IDBP-192813.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aars

Protein Name

alanyl-tRNA synthetase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034441

InnateDB Gene

IDBG-192811 (Aars)

Protein Structure

UniProt Annotation

Function

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255HAMAP-Rule:MF_03133, ECO:0000269PubMed:20010690}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03133}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0003676	nucleic acid binding
GO:0004813	alanine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016597	amino acid binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0046872	metal ion binding

Biological Process

GO:0001942	hair follicle development
GO:0006400	tRNA modification
GO:0006419	alanyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity
GO:0006457	protein folding
GO:0021680	cerebellar Purkinje cell layer development
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034620	cellular response to unfolded protein
GO:0043039	tRNA aminoacylation
GO:0043200	response to amino acid
GO:0043524	negative regulation of neuron apoptotic process
GO:0043588	skin development
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2384560

InterPro

IPR002318 Alanine-tRNA ligase, class IIc
IPR003156 Phosphoesterase, DHHA1
IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
IPR018165 Alanyl-tRNA synthetase, class IIc, core domain

PFAM

PF02272
PF07973
PF01411

PRINTS

PR00980

PIRSF

SMART

SM00863

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt