InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alkbh3

Summary

InnateDB Protein

IDBP-192858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alkbh3

Protein Name

alkB, alkylation repair homolog 3 (E. coli)

Synonyms

1700108H04Rik; 1810020C19Rik; Abh3; mABH3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038721

InnateDB Gene

IDBG-192856 (Alkbh3)

Protein Structure

UniProt Annotation

Function

Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269PubMed:16174769}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in testis, kidney, liver and heart. {ECO:0000269PubMed:16174769}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008198	ferrous iron binding
GO:0016491	oxidoreductase activity
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734	DNA-N1-methyladenine dioxygenase activity
GO:0051747	cytosine C-5 DNA demethylase activity

Biological Process

GO:0006281	DNA repair
GO:0006307	DNA dealkylation involved in DNA repair
GO:0008283	cell proliferation
GO:0035552	oxidative single-stranded DNA demethylation
GO:0055114	oxidation-reduction process