Mus musculus Protein: Tbk1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-192884.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Tbk1 | ||||||||||||||||||||||||
Protein Name | TANK-binding kinase 1 | ||||||||||||||||||||||||
Synonyms | 1200008B05Rik; AI462036; AW048562; | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000020316 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-192882 (Tbk1) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser- 177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. {ECO:0000269PubMed:10581243, ECO:0000269PubMed:15210742, ECO:0000269PubMed:15661922, ECO:0000269PubMed:23396211}. | ||||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. {ECO:0000250}. | ||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 132 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | MGI:1929658 | ||||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain IPR029071 Ubiquitin-related domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q9WUN2 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9WUN2 | ||||||||||||||||||||||||
TrEMBL | Q3THP3 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 56480 | ||||||||||||||||||||||||
UniGene | Mm.34580 | ||||||||||||||||||||||||
RefSeq | NP_062760 | ||||||||||||||||||||||||
MGI ID | 4JLC | ||||||||||||||||||||||||
MGI Symbol | Tbk1 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS24212 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AF145705 AF191839 AK004269 AK004649 AK168193 BC129910 BC129911 CH466578 | ||||||||||||||||||||||||
GenPept | AAD34590 AAF05990 AAI29911 AAI29912 BAB23244 BAB23440 BAE40153 EDL24420 | ||||||||||||||||||||||||