InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ankrd13a

Summary

InnateDB Protein

IDBP-192912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ankrd13a

Protein Name

ankyrin repeat domain 13a

Synonyms

1100001D10Rik; ANKRD13; AU046136;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099638

InnateDB Gene

IDBG-192910 (Ankrd13a)

Protein Structure

UniProt Annotation

Function

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005770	late endosome
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1915670

InterPro

IPR002110 Ankyrin repeat
IPR003903 Ubiquitin interacting motif
IPR020683 Ankyrin repeat-containing domain
IPR021832 Ankyrin repeat domain-containing protein 13

PFAM

PF00023
PF13606
PF02809
PF11929
PF12796
PF11904

PRINTS

PR01415

PIRSF

SMART

SM00248
SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt