InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VRK1

Summary

InnateDB Protein

IDBP-19299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VRK1

Protein Name

vaccinia related kinase 1

Synonyms

PCH1; PCH1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000216639

InnateDB Gene

IDBG-19297 (VRK1)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269PubMed:10951572, ECO:0000269PubMed:14645249, ECO:0000269PubMed:15105425, ECO:0000269PubMed:16495336, ECO:0000269PubMed:18617507, ECO:0000269PubMed:19103756}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Disease Associations

Pontocerebellar hypoplasia 1A (PCH1A) [MIM:607596]: A disorder characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and spinal cord anterior horn cells degeneration resembling infantile spinal muscular atrophy. Additional features include muscle hypotonia, congenital contractures and respiratory insufficiency that is evident at birth. {ECO:0000269PubMed:19646678}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269PubMed:9344656}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031493	nucleosomal histone binding
GO:0035175	histone kinase activity (H3-S10 specific)
GO:0072354	histone kinase activity (H3-T3 specific)

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007077	mitotic nuclear envelope disassembly
GO:0007084	mitotic nuclear envelope reassembly
GO:0043987	histone H3-S10 phosphorylation
GO:0046777	protein autophosphorylation
GO:0072355	histone H3-T3 phosphorylation
GO:0090166	Golgi disassembly

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005795	Golgi stack
GO:0005819	spindle
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt