Version 5.4
Mus musculus Protein: Api5
Summary
InnateDB Protein IDBP-193025.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Api5
Protein Name apoptosis inhibitor 5
Synonyms AAC-11; AI196452;
Species Mus musculus
Ensembl Protein ENSMUSP00000028617
InnateDB Gene IDBG-193023 (Api5)
Protein Structure
UniProt Annotation
Function Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly nuclear.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1888993
InterPro IPR008383 Apoptosis inhibitory 5
IPR016024 Armadillo-type fold
PFAM PF05918
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35841
PhosphoSite PhosphoSite-O35841
TrEMBL
UniProt Splice Variant
Entrez Gene 11800
UniGene Mm.399646
RefSeq NP_031492
MGI ID
MGI Symbol Api5
OMIM
CCDS CCDS16459
HPRD
IMGT
EMBL AK137466 AK153934 AK167375 AL672251 BC007133 CH466519 U35846
GenPept AAB86526 AAH07133 BAE23364 BAE32263 BAE39470 CAM16211 EDL27645

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca