InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Oasl2

Summary

InnateDB Protein

IDBP-193077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oasl2

Protein Name

2'-5' oligoadenylate synthetase-like 2

Synonyms

M1204; Mmu-OASL; Oasl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031542

InnateDB Gene

IDBG-193075 (Oasl2)

Protein Structure

UniProt Annotation

Function

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:12396720, ECO:0000269PubMed:12799444}.

Subcellular Localization

Disease Associations

Tissue Specificity

Strongly expressed in spleen dendritic cells, whereas, in bone marrow-derived dendritic cells, the amount increases during the maturation process. Expressed in many organs, the highest levels being in thymus, lung, and bone marrow. {ECO:0000269PubMed:12396720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001730	2'-5'-oligoadenylate synthetase activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006955	immune response
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0045087	innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1344390

InterPro

IPR000626 Ubiquitin-like
IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF10421
PF11976

PRINTS

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z2F2