InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfwd3

Summary

InnateDB Protein

IDBP-193094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfwd3

Protein Name

ring finger and WD repeat domain 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043780

InnateDB Gene

IDBG-193092 (Rfwd3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0097371	MDM2/MDM4 family protein binding

Biological Process

GO:0006281	DNA repair
GO:0010212	response to ionizing radiation
GO:0016567	protein ubiquitination
GO:0031571	mitotic G1 DNA damage checkpoint
GO:2000001	regulation of DNA damage checkpoint