InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Oasl1

Summary

InnateDB Protein

IDBP-193112.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oasl1

Protein Name

2'-5' oligoadenylate synthetase-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031540

InnateDB Gene

IDBG-193110 (Oasl1)

Protein Structure

UniProt Annotation

Function

Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L. {ECO:0000269PubMed:12396720, ECO:0000269PubMed:12799444}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006955	immune response
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051607	defense response to virus

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2180849

InterPro

IPR000626 Ubiquitin-like
IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF10421
PF11976

PRINTS

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VI94