InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLCE

Summary

InnateDB Protein

IDBP-19318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLCE

Protein Name

glucuronic acid epimerase

Synonyms

HSEPI;

Species

Homo sapiens

Ensembl Protein

ENSP00000261858

InnateDB Gene

IDBG-19316 (GLCE)

Protein Structure

UniProt Annotation

Function

Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. {ECO:0000269PubMed:20118238}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0047464	heparosan-N-sulfate-glucuronate 5-epimerase activity
GO:0050379	UDP-glucuronate 5'-epimerase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0015012	heparan sulfate proteoglycan biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030210	heparin biosynthetic process
GO:0044281	small molecule metabolic process