InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fa2h

Summary

InnateDB Protein

IDBP-193184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fa2h

Protein Name

fatty acid 2-hydroxylase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043597

InnateDB Gene

IDBG-193182 (Fa2h)

Protein Structure

UniProt Annotation

Function

Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids. {ECO:0000269PubMed:15658937, ECO:0000269PubMed:16998236}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15658937}; Multi-pass membrane protein {ECO:0000269PubMed:15658937}. Microsome membrane {ECO:0000269PubMed:15658937}; Multi-pass membrane protein {ECO:0000269PubMed:15658937}.

Disease Associations

Tissue Specificity

Detected in brain and skin (at protein level). Detected in brain white matter, cerebellum forebrain, stomach, kidney, skin and testis. Detected in oligodendrocytes. {ECO:0000269PubMed:15658937, ECO:0000269PubMed:16998236}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0080132	fatty acid alpha-hydroxylase activity

Biological Process

GO:0001949	sebaceous gland cell differentiation
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006665	sphingolipid metabolic process
GO:0030258	lipid modification
GO:0032286	central nervous system myelin maintenance
GO:0032287	peripheral nervous system myelin maintenance
GO:0042127	regulation of cell proliferation
GO:0042634	regulation of hair cycle
GO:0055114	oxidation-reduction process