Version 5.4
Homo sapiens Protein: OLIG1
Summary
InnateDB Protein IDBP-1932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OLIG1
Protein Name oligodendrocyte transcription factor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371785
InnateDB Gene IDBG-1930 (OLIG1)
Protein Structure
UniProt Annotation
Function Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
Disease Associations
Tissue Specificity Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable. {ECO:0000269PubMed:11526205}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0048663 neuron fate commitment
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAK6
PhosphoSite PhosphoSite-Q8TAK6
TrEMBL Q59EM0
UniProt Splice Variant
Entrez Gene 116448
UniGene Hs.725241
RefSeq NP_620450
HUGO HGNC:16983
OMIM 606385
CCDS CCDS42920
HPRD 07333
IMGT
EMBL AB209791 AL834450 AP000289 BC026989 BC033290 BK000278
GenPept AAH26989 AAH33290 BAD93028 CAD39110 DAA01058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca