InnateDB Protein
|
IDBP-193246.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Alkbh7
|
Protein Name
|
alkB, alkylation repair homolog 7 (E. coli)
|
Synonyms
|
2310045B01Rik; 2510008E23Rik; Abh7; Spata11;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000002737
|
InnateDB Gene
|
IDBG-193242 (Alkbh7)
|
Protein Structure
|
|
Function |
Probable dioxygenase required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (By similarity). Involved in fatty acid metabolism. {ECO:0000250, ECO:0000269PubMed:23572141}.
|
Subcellular Localization |
Mitochondrion matrix {ECO:0000269PubMed:23572141}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:23572141}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006631
|
fatty acid metabolic process
|
GO:0006974
|
cellular response to DNA damage stimulus
|
GO:0010883
|
regulation of lipid storage
|
GO:0055114
|
oxidation-reduction process
|
GO:1902445
|
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
|
|
Cellular Component |
|
PDB ID |
MGI:1913650
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9D6Z0
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
66400
|
UniGene |
|
RefSeq |
NP_079814
|
MGI ID |
|
MGI Symbol |
Alkbh7
|
OMIM |
|
CCDS |
CCDS28921
|
HPRD |
|
IMGT |
|
EMBL |
AK007380
AK009812
AK010930
BC029677
GL456179
|
GenPept |
AAH29677
BAB24999
BAB26517
BAB27274
|
|
|