Version 5.4
Mus musculus Protein: Prelp
Summary
InnateDB Protein IDBP-193270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prelp
Protein Name proline arginine-rich end leucine-rich repeat
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000048803
InnateDB Gene IDBG-193268 (Prelp)
Protein Structure
UniProt Annotation
Function May anchor basement membranes to the underlying connective tissue. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity Expressed in cartilage throughout both fetal development and postnatal life. It is also expressed in the developing embryo prior to skeletogenesis. In adult, highest expression in lung, lower levels in cardiac and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0007569 cell aging
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2151110
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01462
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00013
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JK53
PhosphoSite PhosphoSite-
TrEMBL Q543S0
UniProt Splice Variant
Entrez Gene 116847
UniGene Mm.214514
RefSeq NP_473418
MGI ID
MGI Symbol Prelp
OMIM
CCDS CCDS15300
HPRD
IMGT
EMBL AF261887 AF261888 AK047480 BC019775 CH466520
GenPept AAF72994 AAH19775 BAC33072 EDL39632

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca