InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Enpep

Summary

InnateDB Protein

IDBP-193310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Enpep

Protein Name

glutamyl aminopeptidase

Synonyms

6030431M22Rik; APA; Bp-1/6C3; Ly-51; Ly51;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029658

InnateDB Gene

IDBG-193308 (Enpep)

Protein Structure

UniProt Annotation

Function

Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Early B-lineage cells and certain stromal cell of hemopoietic tissues. Also expressed by capillary endothelial cells, placenta, and epithelial cells of the intestine and proximal renal tubules.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0070006	metalloaminopeptidase activity

Biological Process

GO:0001525	angiogenesis
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006508	proteolysis
GO:0008283	cell proliferation
GO:0016477	cell migration
GO:0032835	glomerulus development

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome