InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc119b

Summary

InnateDB Protein

IDBP-193362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc119b

Protein Name

unc-119 homolog B (C. elegans)

Synonyms

AA407659; AI414892;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055475

InnateDB Gene

IDBG-193360 (Unc119b)

Protein Structure

UniProt Annotation

Function

Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium {ECO:0000250}. Note=Enriched at the transition zone and extended into the proximal end of the cilium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0042953	lipoprotein transport
GO:0060271	cilium morphogenesis

Cellular Component

GO:0035869

ciliary transition zone

Protein Structure and Domains

PDB ID

MGI:2147162

InterPro

IPR008015 GMP phosphodiesterase, delta subunit
IPR014756 Immunoglobulin E-set

PFAM

PF05351

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C4B4

PhosphoSite

PhosphoSite-Q8C4B4

TrEMBL

UniProt Splice Variant

Entrez Gene

106840

UniGene

Mm.29241

RefSeq

NP_780561

MGI ID

MGI Symbol

Unc119b

OMIM

CCDS

CCDS19580

HPRD

IMGT

EMBL

AK045128 AK082614 BC008617 BC112388 BC115529

GenPept

AAH08617 AAI12389 AAI15530 BAC32235 BAC38549