InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tas2r130

Summary

InnateDB Protein

IDBP-193482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tas2r130

Protein Name

taste receptor, type 2, member 130

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063954

InnateDB Gene

IDBG-193480 (Tas2r130)

Protein Structure

UniProt Annotation

Function

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in gastric and duodenal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004930	G-protein coupled receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste