InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tas2r105

Summary

InnateDB Protein

IDBP-193528.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tas2r105

Protein Name

taste receptor, type 2, member 105

Synonyms

mGR05; mt2r5; T2R05; T2r5; T2R9; Tas2r5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058006

InnateDB Gene

IDBG-193526 (Tas2r105)

Protein Structure

UniProt Annotation

Function

Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium- regulated cation channel TRPM5. {ECO:0000269PubMed:10761935, ECO:0000269PubMed:15759003}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in gastric and duodenal tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste
GO:0050912	detection of chemical stimulus involved in sensory perception of taste
GO:0050913	sensory perception of bitter taste