InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Usp15

Summary

InnateDB Protein

IDBP-193534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Usp15

Protein Name

ubiquitin specific peptidase 15

Synonyms

4921514G19Rik; AI327321; E430033I05Rik; Gcap18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020334

InnateDB Gene

IDBG-193532 (Usp15)

Protein Structure

UniProt Annotation

Function

Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in testis, heart and liver. {ECO:0000269PubMed:12532266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 94 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	94 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005160	transforming growth factor beta receptor binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0042802	identical protein binding
GO:0046332	SMAD binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016579	protein deubiquitination
GO:0030509	BMP signaling pathway
GO:0035520	monoubiquitinated protein deubiquitination
GO:0060389	pathway-restricted SMAD protein phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:101857

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
IPR013792 RNA 3\'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00443
PF06337

PRINTS

PIRSF

SMART

SM00695

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R5H1