InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acan

Summary

InnateDB Protein

IDBP-193559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acan

Protein Name

aggrecan

Synonyms

Agc; Agc1; b2b183Clo; cmd; Cspg1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032835

InnateDB Gene

IDBG-193557 (Acan)

Protein Structure

UniProt Annotation

Function

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Note=Defects in Acan are the cause of cartilage matrix deficiency (CMD). CMD is an autosomal recessive syndrome characterized by cleft palate, short limbs, tail and snout. Mutation in strain CMD causes absence of aggrecan by truncation of the protein (mutation in the G1 domain).

Tissue Specificity

Specifically expressed in cartilage tissues. {ECO:0000269PubMed:7524681}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

Biological Process

GO:0001502	cartilage condensation
GO:0002063	chondrocyte development
GO:0007155	cell adhesion
GO:0030166	proteoglycan biosynthetic process
GO:0030199	collagen fibril organization

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:99602

InterPro

IPR000436 Sushi/SCR/CCP
IPR000538 Link
IPR001304 C-type lectin
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00084
PF00193
PF00059
PF07686

PRINTS

PR01265

PIRSF

SMART

SM00032
SM00445
SM00034
SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt