Mus musculus Protein: Clec10a
Summary
InnateDB Protein IDBP-193588.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clec10a
Protein Name C-type lectin domain family 10, member A
Synonyms CD301a; M-ASGP-BP-1; Mgl; Mgl1;
Species Mus musculus
Ensembl Protein ENSMUSP00000099631
InnateDB Gene IDBG-193586 (Clec10a)
Protein Structure
UniProt Annotation
Function Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity. {ECO:0000269PubMed:19995956}.
Subcellular Localization Membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Detected in lymph node in the subcapsular sinus, interfollicular regions, T and B-cell boundary and in the areas surrounding high endothelial venules (at protein level). Expressed on the surface of activated macrophages. Expressed in heart, lung, testis, skeletal muscle, spleen, brain, kidney and thymus. Expressed in P388, RAW 264.7 and M1 cell lines. {ECO:0000269PubMed:12016228, ECO:0000269PubMed:15364954}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:96975
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR005640 Hepatic lectin, N-terminal
IPR009053 Prefoldin
IPR016187 C-type lectin fold
PFAM PF00059
PF03954
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49300
PhosphoSite PhosphoSite-P49300
TrEMBL A2CF63
UniProt Splice Variant
Entrez Gene 17312
UniGene Mm.486966
RefSeq NP_034926
MGI ID
MGI Symbol Clec10a
OMIM
CCDS CCDS24936
HPRD
IMGT
EMBL AF132744 AL669869 BC014811 CH466596 CR933731 S36676
GenPept AAB22171 AAD31028 AAH14811 CAI35217 CAM28085 EDL12536