InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gar1

Summary

InnateDB Protein

IDBP-193615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gar1

Protein Name

GAR1 ribonucleoprotein homolog (yeast)

Synonyms

AA409823; AI326794; C430047J18Rik; Nola1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029643

InnateDB Gene

IDBG-193613 (Gar1)

Protein Structure

UniProt Annotation

Function

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Also localized to Cajal bodies (coiled bodies). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001522	pseudouridine synthesis
GO:0006364	rRNA processing
GO:0042254	ribosome biogenesis

Cellular Component

GO:0001651	dense fibrillar component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0031429	box H/ACA snoRNP complex

Protein Structure and Domains

PDB ID

MGI:1930948

InterPro

IPR007504 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1
IPR009000 Translation protein, beta-barrel domain

PFAM

PF04410

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CY66

PhosphoSite

PhosphoSite-Q9CY66

TrEMBL

D3YZ09

UniProt Splice Variant

Entrez Gene

68147

UniGene

RefSeq

NP_080854

MGI ID

MGI Symbol

Gar1

OMIM

CCDS

CCDS38634

HPRD

IMGT

EMBL

AC111097 AK021256 AK075923 BC021873 BC048685

GenPept

AAH21873 AAH48685 BAB32351 BAC36056