InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msl2

Summary

InnateDB Protein

IDBP-193618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msl2

Protein Name

male-specific lethal 2 homolog (Drosophila)

Synonyms

E130103E02Rik; Msl2l1; Rnf184;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082270

InnateDB Gene

IDBG-193616 (Msl2)

Protein Structure

UniProt Annotation

Function

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure (By similarity). Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0043984

histone H4-K16 acetylation

Cellular Component

GO:0072487

MSL complex

Protein Structure and Domains

PDB ID

MGI:1925103

InterPro

IPR001841 Zinc finger, RING-type

PFAM

PF13639
PF14634

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q69ZF8

PhosphoSite

PhosphoSite-Q69ZF8

TrEMBL

UniProt Splice Variant

Entrez Gene

77853

UniGene

Mm.490380

RefSeq

NP_001093921

MGI ID

MGI Symbol

Msl2

OMIM

CCDS

HPRD

IMGT

EMBL

AK035934 AK173208 BC100371

GenPept

AAI00372 BAC29248 BAD32486