InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cfdp1

Summary

InnateDB Protein

IDBP-193636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cfdp1

Protein Name

craniofacial development protein 1

Synonyms

AA408409; Bcnt; Bucentaur; Cfdp; cp27;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034432

InnateDB Gene

IDBG-193634 (Cfdp1)

Protein Structure

UniProt Annotation

Function

May play a role during embryogenesis. May modulate tooth organogenesis since alterations of this protein function affect tooth organs size as well as individual cell fate and survival. In embryonic cells, blockage of the function results in increased number of apoptotic cells, reduced proliferation, alterations in cell shape and fibronection matrix synthesis. {ECO:0000269PubMed:10415329, ECO:0000269PubMed:11992732, ECO:0000269PubMed:12153613}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in lung, liver and heart, with higher expression in teeth. {ECO:0000269PubMed:10415329}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0008360	regulation of cell shape
GO:0042127	regulation of cell proliferation
GO:2000270	negative regulation of fibroblast apoptotic process

Cellular Component

GO:0005604

basement membrane

Protein Structure and Domains

PDB ID

MGI:1344403

InterPro

IPR011421 BCNT-C domain

PFAM

PF07572

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88271

PhosphoSite

PhosphoSite-O88271

TrEMBL

UniProt Splice Variant

Entrez Gene

23837

UniGene

RefSeq

NP_035931

MGI ID

MGI Symbol

Cfdp1

OMIM

CCDS

CCDS22680

HPRD

IMGT

EMBL

AB010828 AB033766 AK133989 AK160532 BC005589 Y08219

GenPept

AAH05589 BAA31696 BAA94844 BAE21971 BAE35849 CAA69396