InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cfi

Summary

InnateDB Protein

IDBP-193656.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cfi

Protein Name

complement component factor i

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077074

InnateDB Gene

IDBG-193652 (Cfi)

Protein Structure

UniProt Annotation

Function

Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0006952	defense response
GO:0006958	complement activation, classical pathway
GO:0045087	innate immune response

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:105937

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR002350 Kazal domain
IPR003614 Knottin, scorpion toxin-like
IPR003884 Factor I / membrane attack complex
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF00050
PF07648

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00280
SM00505
SM00057
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt