Version 5.4
Mus musculus Protein: Tas2r121
Summary
InnateDB Protein IDBP-193665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tas2r121
Protein Name taste receptor, type 2, member 121
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000093044
InnateDB Gene IDBG-193663 (Tas2r121)
Protein Structure
UniProt Annotation
Function Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). {ECO:0000250UniProtKB:Q9NYV9}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2681259
InterPro IPR007960 Mammalian taste receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF05296
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7M720
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 387349
UniGene Mm.377911
RefSeq NP_996907
MGI ID
MGI Symbol Tas2r121
OMIM
CCDS CCDS20618
HPRD
IMGT
EMBL AC124523 BC104410 BC104411 BK001077
GenPept AAI04411 AAI04412 DAA01216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca