Version 5.4
| Mus musculus Protein: Lrig3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-193692.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Lrig3 | ||||||||
| Protein Name | leucine-rich repeats and immunoglobulin-like domains 3 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000074360 | ||||||||
| InnateDB Gene | IDBG-193690 (Lrig3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. {ECO:0000269PubMed:19004851, ECO:0000269PubMed:20126551}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:20126551}; Single-pass type I membrane protein {ECO:0000269PubMed:20126551}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:20126551}; Single-pass type I membrane protein {ECO:0000269PubMed:20126551}. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed. {ECO:0000269PubMed:15203213}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2443955 | ||||||||
| InterPro |
IPR000483
Cysteine-rich flanking region, C-terminal IPR001611 Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype IPR003598 Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013151 Immunoglobulin |
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| PFAM |
PF01463
PF00560 PF13504 PF13855 PF07679 PF00047 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00082
SM00369 SM00408 SM00409 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6P1C6 | ||||||||
| PhosphoSite | PhosphoSite-Q6P1C6 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 320398 | ||||||||
| UniGene | Mm.481277 | ||||||||
| RefSeq | NP_796126 | ||||||||
| MGI ID | 3SO5 | ||||||||
| MGI Symbol | Lrig3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS24219 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK044994 AK078783 AK129481 AY505341 BC065142 | ||||||||
| GenPept | AAH65142 AAR98630 BAC32175 BAC37394 BAC98291 | ||||||||