InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdhx

Summary

InnateDB Protein

IDBP-193703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdhx

Protein Name

pyruvate dehydrogenase complex, component X

Synonyms

AI481367; E3bp; Pdx1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000011058

InnateDB Gene

IDBG-193701 (Pdhx)

Protein Structure

UniProt Annotation

Function

Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1351627

InterPro

IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR004167 E3 binding
IPR011053 Single hybrid motif

PFAM

PF00364
PF00198
PF02817

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BKZ9

PhosphoSite