InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chst5

Summary

InnateDB Protein

IDBP-193712.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chst5

Protein Name

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

Synonyms

AI173964; Gn6st-3; GST-4; I-GlcNAc-6-ST;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034430

InnateDB Gene

IDBG-193710 (Chst5)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N- acetyllactosamine structures. May also have activity toward O- linked sugars of mucin-type acceptors. {ECO:0000269PubMed:12218059}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Golgi membrane, early secretory pathway. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in cornea. {ECO:0000269PubMed:11278593}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006790	sulfur compound metabolic process
GO:0018146	keratan sulfate biosynthetic process