InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd70

Summary

InnateDB Protein

IDBP-193727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd70

Protein Name

CD70 antigen

Synonyms

Cd27l; CD27LG; Tnfsf7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019633

InnateDB Gene

IDBG-193725 (Cd70)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. {ECO:0000269PubMed:9620608}.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Very low level of expression. Detected in splenocytes and thymocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome